Tissue engineering strategies for promoting vascularized bone regeneration
نویسندگان
چکیده
منابع مشابه
Engineering Pre-vascularized Scaffolds for Bone Regeneration.
Survival of functional tissue constructs of clinically relevant size depends on the formation of an organized and uniformly distributed network of blood vessels and capillaries. The lack of such vasculature leads to spatio-temporal gradients in oxygen, nutrients and accumulation of waste products inside engineered tissue constructs resulting in negative biological events at the core of the scaf...
متن کاملPorous ceramic bone scaffolds for vascularized bone tissue regeneration.
Hydroxyapatite scaffolds with a multi modal porosity designed for use in tissue engineering of vascularized bone graft substitutes were prepared by three dimensional printing. Depending on the ratio of coarse (mean particle size 50 microm) to fine powder (mean particle size 4 microm) in the powder granulate and the sintering temperature total porosity was varied from 30% to 64%. While macroscop...
متن کاملA Review on Commonly Used Scaffolds in Tissue Engineering for Bone Tissue Regeneration
Introduction: Bone is one of the tissues that have a true potential for regeneration. However, sometimes the bone defects are so outsized that there is no chance of bone self-repair and restoration or the damage is such that it is not possible to repair with medical or surgical interventions. In these situations, bone grafts are the treatment of choice, but due to several obstacles, including l...
متن کاملBone Tissue Engineering and Regeneration
1 Department of Surgery, University of Michigan Health Systems, Taubman Center, 1500 East Medical Center Drive, XPC 5340, Ann Arbor, MI 48109-0219, USA 2Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, 615 Charles E. Young Drive South, Room 410, Los Angeles, CA 90095, USA 3 Center for Cardiovascular Science and MRC Center for Regenerat...
متن کاملVascularized bone tissue engineering: approaches for potential improvement.
Significant advances have been made in bone tissue engineering (TE) in the past decade. However, classical bone TE strategies have been hampered mainly due to the lack of vascularization within the engineered bone constructs, resulting in poor implant survival and integration. In an effort toward clinical success of engineered constructs, new TE concepts have arisen to develop bone substitutes ...
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ژورنال
عنوان ژورنال: Bone
سال: 2016
ISSN: 8756-3282
DOI: 10.1016/j.bone.2015.11.011